diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 2e6a882ac..d10eca098 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -120,14 +120,12 @@ jobs:
             timeout: 10
             os: "macos-14"
             arch: arm64
-            version: "11"
             shell: "/usr/bin/arch -arch arm64e /bin/bash --noprofile --norc -eo pipefail {0}"
 
           - name: "macos-10-intel"
             timeout: 20
             os: "macos-14-large"
             arch: x64
-            version: "10.14"
             shell: "bash"
 
     steps:
@@ -140,8 +138,6 @@ jobs:
         run: ./scripts/install_deps.py
 
       - name: Configure
-        env:
-          CMAKE_OSX_DEPLOYMENT_TARGET: ${{ matrix.target.version }}
         run: cmake -B build --preset=macos-release -DCMAKE_PREFIX_PATH=$(brew --prefix qt@6)
 
       - name: Build
diff --git a/ChangeLog b/ChangeLog
index 0042ebdee..b062421e4 100644
--- a/ChangeLog
+++ b/ChangeLog
@@ -48,6 +48,7 @@ Enhancements:
 - #7378 Improve workflow triggers to ensure correct run time
 - #7379 Resolve Qt framework path with `install_name_tool`
 - #7380 Add `qt6-qpa-plugins` Qt dependency for Debian
+- #7381 Set macOS min version to macOS 12.0
 
 # 1.14.6
 
diff --git a/cmake/Definitions.cmake b/cmake/Definitions.cmake
index 272930b84..e43b59268 100644
--- a/cmake/Definitions.cmake
+++ b/cmake/Definitions.cmake
@@ -22,6 +22,10 @@ macro(configure_definitions)
   set(CMAKE_RUNTIME_OUTPUT_DIRECTORY "${CMAKE_BINARY_DIR}/bin")
   set(CMAKE_LIBRARY_OUTPUT_DIRECTORY "${CMAKE_BINARY_DIR}/lib")
 
+  if(APPLE)
+    set(CMAKE_OSX_DEPLOYMENT_TARGET "12.0")
+  endif()
+
   configure_ninja()
   configure_options()
 
diff --git a/cmake/Libraries.cmake b/cmake/Libraries.cmake
index dfe6b0196..65f0b3844 100644
--- a/cmake/Libraries.cmake
+++ b/cmake/Libraries.cmake
@@ -149,23 +149,6 @@ macro(configure_mac_libs)
       "--sysroot ${CMAKE_OSX_SYSROOT} ${CMAKE_CXX_FLAGS} -DGTEST_USE_OWN_TR1_TUPLE=1"
   )
 
-  if(NOT CMAKE_OSX_DEPLOYMENT_TARGET)
-    set(CMAKE_OSX_DEPLOYMENT_TARGET 11.0)
-  endif()
-
-  if(CMAKE_OSX_DEPLOYMENT_TARGET GREATER_EQUAL 11.0)
-    set(SYNERGY_OSX_DEPLOYMENT_TARGET 1100)
-  elseif(CMAKE_OSX_DEPLOYMENT_TARGET GREATER_EQUAL 10.15)
-    set(SYNERGY_OSX_DEPLOYMENT_TARGET 1015)
-  elseif(CMAKE_OSX_DEPLOYMENT_TARGET GREATER_EQUAL 10.14)
-    set(SYNERGY_OSX_DEPLOYMENT_TARGET 1014)
-  else()
-    set(SYNERGY_OSX_DEPLOYMENT_TARGET 1013)
-  endif()
-
-  add_compile_definitions(
-    OSX_DEPLOYMENT_TARGET=${SYNERGY_OSX_DEPLOYMENT_TARGET})
-
   find_library(lib_ScreenSaver ScreenSaver)
   find_library(lib_IOKit IOKit)
   find_library(lib_ApplicationServices ApplicationServices)
@@ -181,10 +164,8 @@ macro(configure_mac_libs)
     ${lib_Foundation}
     ${lib_Carbon})
 
-  if(SYNERGY_OSX_DEPLOYMENT_TARGET GREATER_EQUAL 1014)
-    find_library(lib_UserNotifications UserNotifications)
-    list(APPEND libs ${lib_UserNotifications})
-  endif()
+  find_library(lib_UserNotifications UserNotifications)
+  list(APPEND libs ${lib_UserNotifications})
 
   add_definitions(-DWINAPI_CARBON=1 -D_THREAD_SAFE)